Friday, April 18, 2025

Auvelity Prescription Update

Axsome Therapeutic's drug, Auvelity was approved for depression in 2022, and completed it's first full year in 2023. The chart below is quarterly prescription data derived from a couple different sources, Bloomberg and IQVIA. The numbers are climbing from quarter to quarter, which is positive. The first quarter of 2025 numbers have not been released yet, so a rough estimate has been created. See chart below. Axsome reports first quarter results on May 5th.

Thursday, April 10, 2025

GOLD - New High

Previous gold post's are here Gold Showing Strength and here Gold Revaluation. The tariffs bought a new high to gold, along with wealth preservation amidst fiat currency devaluation, and geo political uncertainty. It would seem all is in favor of owning physical gold, or at the very least, have assets invested in gold funds. Gold hit $3,184 per ounce today with no overhead resistance to higher prices. If you have a chance to read  Fiat Money Inflation in France, it would be an eye opener regarding fiat currency and similarities, historically to today. Chart of gold. Thank you for reading.

Wednesday, April 2, 2025

Solriamfetol for ADHD Phase 3 Results

Axsome released phase 3 clinical data from the (FOCUS) study with drug Solriamfetol for Attention Deficit Hyperactivity Disorder (ADHD), with results being statistically significant, rated under the AISRS (primary endpoint) versus placebo with 150mg dose.

FOCUS Phase 3 Results:

  • AISRS compared to placebo p=0.039 
  • CGI-S compared to placebo p=0.017
The company will next have to run a pediatric phase 3 study scheduled for 2025. If positive then can submit to the FDA a new drug application. The advantage over current treatments, is that Solriamfetol is considered a non-stimulant drug, and potential improvement from a safety profile from currently approved ADHD drugs on the market. Thank you for reading.